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Cardiac Risk Higher With Rosiglitazone Than Pioglitazone

Author and Disclosure Information

Major Finding: Patients taking rosiglitazone had significantly increased risks of myocardial infarction (odds ratio, 1.16), heart failure (OR, 1.22), and death (OR, 1.14), compared with those taking pioglitazone.

Data Source: A meta-analysis of 16 studies in 810,000 thiazolidinedione users.

Disclosures: Dr. Loke and his colleagues declared no conflicts of interest in their meta-analysis.

FROM BMJ

Dr. Loke and his colleagues declared no conflicts of interest in their meta-analysis. Dr. Montori and Dr. Shaw reported having no competing interests. Dr. Kaul also disclosed none related to his conclusions.