Conference Coverage

Chlamydia infections associated with more than a doubling of ovarian cancer risk


Key clinical point: Chlamydia infections appear to increase the risk of ovarian cancer.

Major finding: The presence of an antibody to chlamydia increased the chance of ovarian cancer by up to 2.25-fold (OR 2.25).

Study details: The cohorts comprised 278 cases vs. 556 controls from a Polish study, and 160 cases vs. 159 controls from a U.S. study.

Disclosures: The NCI Intramural Research Program supported the study. The researchers declared no conflicts of interest.

Source: Trabet et al. Abstract 4942.



Pelvic inflammatory disease caused by chlamydia appears to significantly increase the risk of ovarian cancer, according to research to be presented at the annual meeting of the American Association for Cancer Research.

The finding, replicated in two large databases, suggests that promptly treating the infection might reduce the lifetime risk of developing ovarian cancer, Britton Trabert, PhD, said during a press briefing held in advance of the meeting.

Dr. Britton Trabert, National Cancer Institute, Bethesda, Md.

Dr. Britton Trabert

“Although these findings need to be replicated, they suggest potential ovarian cancer risk reduction through targeted treatment of chlamydia infections,” said Dr. Trabert, the Earl Stadtman Investigator at the National Cancer Institute.

The study portends both promise and challenge, according to Elaine R. Mardis, PhD, who comoderated the session.


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