Two meals per day better than six in T2DM
AT THE ADA ANNUAL SCIENTIFIC SESSIONS
Both parameters of beta-cell function – insulin secretion and glucose sensitivity – increased comparably with the two diets, Dr. Kahleová said. Changes in glucose sensitivity (P = .02) and oral glucose insulin sensitivity (P less than .001) correlated negatively with the change in hepatic fat content. The correlations were no longer significant, however, after adjustment for changes in BMI.
Dr. Kahleová said the results were as expected, and she declined to speculate as to whether they would be the same if the cohort had been heavier than allowed with the BMI inclusion criteria of 27-40 kg/m2.
The investigators are currently trying to find a link between postprandial oxidative stress and gastrointestinal peptides in patients with type 2 diabetes.
The study was supported by a grant from the Ministry of Health, Prague, and by the Grant Agency of Charles University, also in Prague. Dr. Kahleová reported having no financial disclosures.
