New Methods Found Promising for Predicting CKD Progression

Major Finding: A triple-marker method incorporating serum creatinine, serum cystatin C, and albuminuria levels predicted CKD progression more accurately than did standard creatinine-estimated GFR alone. Another model incorporating seven patient variables also was more accurate at predicting disease progression than was standard creatinine-estimated GFR alone.

Data Source: The first study was a secondary analysis of a population-based cohort involving 26,643 adults. The second study was an analysis of CKD outcomes following the development and validation of seven models for predicting disease progression in adults with stage 3-5 CKD.

Disclosures: Dr. Peralta’s study was supported by the National Institute of Neurological Disorders and Stroke, Amgen Corp., the National Institute of Diabetes and Digestive and Kidney Diseases, the Robert Wood Johnson Foundation, and the American Heart Association. Several associates also reported ties to Amgen. Dr. Tangri’s study was supported by a joint initiative of the Kidney Foundation of Canada, the Canadian Institute of Health Research, and the Canadian Society of Nephrology, as well as by the Change Foundation of Ontario. Dr. Tangri and associates reported no financial conflicts of interest.