PRECOMBAT: For Left Main Disease, PCI Not Inferior to CABG
Major Finding: At 2 years, the composite of death, myocardial infarction and stroke was 4.4% in the PCI group and 4.7% in the CABG group. The major difference was the rate of ischemia-driven target-vessel revascularization, which was 9% with PCI and 4.2% with CABG.
Data Source: Median 2-year follow-up of patients with unprotected left main coronary artery stenosis randomized to undergo PCI with a sirolimus-eluting stent (n = 300) or CABG (n = 300).
Disclosures: Dr. Park reported receiving consulting fees and honoraria from Johnson & Johnson and Cordis.
FROM THE ANNUAL MEETING OF THE AMERICAN COLLEGE OF CARDIOLOGY
Event rates at 1 year in SYNTAX were higher than those in PRECOMBAT, and the PRECOMBAT patient population had less complex disease, lower SYNTAX scores, and less comorbidity, according to Dr. Park.
At a press briefing discussion of the results, Dr. Spencer King, professor of medicine emeritus at Emory University, Atlanta, remarked that "Certainly, (the PRECOMBAT) results are very consistent with the SYNTAX results and add more evidence to the benefit of intervention in left main cases."
