C. difficile Epidemic Still Poses Clinical Challenges

The new emphasis on prevention of health care-acquired infections could make a difference, Dr. McDonald noted. The CDC is working with hospitals to prevent outbreaks by revising antimicrobial prescribing practices as well as environmental efforts, such as using gowns and enforcing hand-washing rules. “Data suggest that many more cases of CDI can be prevented than we currently realize. … It seems like it's something that will require a new way of doing business with regard to infection-control measures.”

Dr. Pepin is on the advisory board for Acambis, which is developing a C. difficile vaccine. Dr. Gerding holds patents for the treatment and prevention of CDI licensed to ViroPharma Inc., and is a consultant for and/or holds research grants from several companies. Dr. Peterson has received research funding and/or consulting fees from several companies and the National Institutes of Health. Dr. McDonald reported having nothing to disclose.