Conference Coverage

Empiric fluid restriction cuts transsphenoidal surgery readmissions


Key clinical point: A simple fluid restriction protocol cuts readmissions 70% following transsphenoidal surgery.

Major finding: The readmission rate among the transsphenoidal surgery patients was 7.6% before the fluid restriction protocol was implemented, compared with 2.4% (P = .044) afterward.

Study details: Review of 287 transsphenoidal surgery patients.

Disclosures: The National Institutes of Health supported the work. The investigators did not have any disclosures.

Source: Deaver KE et al. Abstract SUN-572



– A 70% drop in 30-day readmissions following transsphenoidal surgery was achieved at the University of Colorado, Aurora, after endocrinologists there restricted fluid for the first 2 weeks postop, according to a report at the Endocrine Society annual meeting.

The antidiuretic hormone (ADH) rebound following pituitary adenoma resection often leads to fluid retention, and potentially dangerous hyponatremia, in about 25% of patients. It’s the leading cause of readmission for this procedure, occurring in up to 15% of patients.

To counter the problem, endocrinology fellow Kelsi Deaver, MD, and her colleagues limited patients to 1.5 L of fluid for 2 weeks after discharge, with a serum sodium check at day 7. If the sodium level was normal, patients remained on 1.5 L until the 2-week postop visit. If levels trended upward – a sign of dehydration – restrictions were eased to 2 or even 3 L, which is about the normal daily intake. If sodium levels trended downward, fluids were tightened to 1-1.2 L, or patients were brought in for further workup. The discharge packet included a 1.5-L cup so patients could track their intake.

Among 118 patients studied before the protocol was implemented in September 2015, 9 (7.6%) were readmitted for symptomatic hyponatremia within 30 days. Among 169 studied after the implementation of the fluid restriction protocol, just 4 (2.4%) were readmitted for hyponatremia (P = .044).

Dr. Kelsi Deaver, endocrinology fellow at University of Colorado, Aurora

Dr. Kelsi Deaver

“What was surprising is that we did not have any readmissions for dehydration/hypernatremia. That was the biggest [concern] among physicians, that we are going to dry out these patients and they would come back severely dehydrated. We didn’t see that.” With the protocol’s success, “this is now the routine management that all our endocrinologist attendings use,” Dr. Deaver said.

At present, there are no widely accepted postop fluid management guidelines for transsphenoidal surgery, but some hospitals have taken similar steps, she said.

It was the fluid restriction, not the 7-day sodium check, that drove the results. Among the four readmissions after the protocol took effect, two patients had their sodium checked, and two did not because their sodium drop was so precipitous that they were back in the hospital before the week was out. Overall, only about 70% of patients got their sodium checked as instructed.

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