Case-Based Review

Savvy Psychopharmacology

Psychotropic-induced hyponatremia

Hyponatremia is a common, multifactorial clinical condition. Hyponatremia is usually defined as a plasma sodium level <135 mmol/L; however,...

Cases That Test Your Skills

The teenager who couldn’t stay awake

Mr. G, age 14, presents to the ED with hypersomnolence and altered mental status. Drug screens are negative. What could be causing these symptoms...

Savvy Psychopharmacology

Managing procedural pain in a patient taking naltrexone

Mr. M, age 55, presents to his primary care physician (PCP) with hematochezia. Mr. M states that for the past week, he has noticed blood upon...

Cases That Test Your Skills

Bugs on her skin—but nobody else sees them

Ms. L, age 74, presents to the ED with multiple excoriations after attempting to kill bugs on and in her skin. Clinicians are unable to find any...

Savvy Psychopharmacology

Making sense of CYP2D6 and CYP1A2 genotype vs phenotype

The clinical response to the same dose of a drug may vary among individuals. Cytochrome P450 (CYP) 2D6 and 1A2 are enzymes that metabolize many...