Bacterial Conjunctivitis and Resistance

In contrast, the fluoroquinolones have been well tolerated and associated with less toxicity than the other ophthalmic antibacterial classes, although crystalline precipitates have been seen with ciprofloxacin when it is administered frequently.

The ideal treatment for acute bacterial conjunctivitis should be a well-tolerated, broad-spectrum, highly potent, and bactericidal agent with a high concentration on the ocular surface and a rapid kill time. Convenience in dosing is also an important consideration. The newer fluoroquinolones, with potent efficacy against H. influenzae and Strep. pneumoniae, may best fulfill those requirements. But of course, cost remains a problem for many.