Conference Coverage

Bleeding episodes more common in boys with VWD

 

Key clinical point: Higher rates of bleeding and treatment use were seen among boys, compared with girls with von Willebrand disease.

Major finding: A higher proportion of boys than girls reported ever having a bleeding episode among children with type 1 VWD (78% vs. 73%; P= .01) and type 2 VWD (90% vs. 75%; P= .01), but not among children with type 3 VWD (97% vs. 96%; P= .77).

Study details: An analysis of 2,413 children with VWD aged 2-12 years.

Disclosures: Dr. Abe reported having no financial disclosures.

Source: Abe K et al. THSNA 2018, Poster 145.


 

REPORTING FROM THSNA 2018

– Among children with types 1 and 2 von Willebrand disease (VWD), a higher proportion of boys than girls reported ever having a bleeding episode and using more treatment products. But the trend did not continue among children with type 3 disease.

Those are some of the key findings from a never-before-published analysis of surveillance data from the Centers for Disease Control and Prevention presented by Karon Abe, PhD, during a poster session at the biennial summit of the Thrombosis & Hemostasis Societies of North America.

Dr. Karon Abe is chief of the epidemiology and surveillance branch in the division of blood disorders at the CDC’s National Center on Birth Defects and Developmental Disabilities Doug Brunk/MDedge News

Dr. Karon Abe

Dr. Abe, chief of the epidemiology and surveillance branch in the division of blood disorders at the CDC’s National Center on Birth Defects and Developmental Disabilities, and her associates set out to assess the differences in bleeding characteristics among preadolescent boys and girls by VWD type.

The researchers retrieved data from the UDC (Universal Data Collection System), a federally funded surveillance system of people with hemophilia and other bleeding disorders treated at 130 U.S. Hemophilia Treatment Centers (HTCs) during 1998-2011. Although UDC data collection ended in 2011, a current CDC bleeding surveillance project called Community Counts continues and expands on the work of the UDC.

Between 1998 and 2011, data were collected on 2,413 children with VWD aged 2-12 years. Of these, 2,070 had type 1, 224 had type 2, and 119 had type 3 VWD. The researchers used chi-square analysis and Wilcoxon rank sum tests to assess differences in bleeding characteristics by sex and by type of VWD. Next, they used a multivariate regression model to examine the association between demographic and clinical characteristics and a history of ever having had a bleeding episode among type 1 VWD patients.

Nearly two-thirds of children (65%) were non-Hispanic, 17% were Hispanic, 8% were black, and the remainder were from other ethnicities. In addition, 40% of the children had no family history of a bleeding disorder.

The median age of first bleed was lower among children with type 3 VWD, compared with other VWD types, and was lower among boys than girls with type 1 VWD (36 months vs. 48 months, respectively; P less than .001) and type 3 VWD (9 months vs. 12 months; P = .04), Dr. Abe reported.

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