Do progestational compounds reduce preterm delivery in high-risk gravidas?

Bottom Line

Progesterone supplementation to prevent preterm birth remains investigational. Further studies are needed to evaluate its effectiveness in decreasing preterm delivery rates in high- and low-risk populations and to better understand its mechanism of action.

Given the absence of proven alternatives, however, it may be appropriate to offer such treatment to patients at highest risk for early preterm birth, such as those with higher-order multifetal pregnancies or a history of recurrent preterm deliveries. Evidence is insufficient to recommend progesterone treatment for women presenting in acute preterm labor.