News Roundup: New and Noteworthy Information

Patients with subjective cognitive impairment (SCI) might be in the early stages of Alzheimer’s disease, suggests a report in the July Lancet Neurology. Investigators observed patients with SCI, amnestic mild cognitive impairment (aMCI), and nonamnestic mild cognitive impairment (naMCI). A CSF Alzheimer’s disease profile was defined as an abnormal ratio of β-amyloid 42 to tau. Outcome measures included changes in memory, overall cognition, Mini-Mental State Examination score, daily function, and progression to dementia of the Alzheimer’s disease type. “The CSF Alzheimer’s disease profile was more common in patients with SCI (31 of 60 [52%]), naMCI (25 of 37 [68%]), and aMCI (56 of 71 [79%]), than in healthy controls (28 of 89 [31%]),” the researchers stated. In addition, the CSF Alzheimer’s disease profile was predictive of Alzheimer’s disease–type dementia in subjects with MCI.

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—Laura Sassano