Early Surgical Menopause Is Linked to Cognitive Decline
Dr. Bove noted certain limitations of the study, including the fact that study participants were required to be nondemented at baseline. “This may have led to exclusion bias if there were early effects of menopause on cognitive function,” Dr. Bove said. “The cognitive outcomes were weighted toward memory, and the reproductive histories were patient reported and retrospective, so there’s a limited definition of surgical menopause. We don’t have any information as to whether the oophorectomies were unilateral or bilateral, or the indication for the surgeries. There were also limited data about HRT use.”
—Doug Brunk
IMNG Medical News
Suggested Reading
Henderson VW, St John JA, Hodis HN, et al. Long-term soy isoflavone supplementation and cognition in women: a randomized, controlled trial. Neurology. 2012;78(23):1841-1848.
Vaughan L, Espeland MA, Snively B, et al. The rationale, design, and baseline characteristics of the Women’s Health Initiative Memory Study of Younger Women (WHIMS-Y). Brain Res. 2013 Apr 8 [Epub ahead of print].
Vearncombe KJ, Rolfe M, Andrew B, et al. Cognitive effects of chemotherapy-induced menopause in breast cancer. Clin Neuropsychol. 2011;25(8):1295-1313.
