No gain seen from adjuvant bevacizumab in HER2-positive disease

Additionally, the rate of invasive disease–free survival was statistically indistinguishable with or without bevacizumab in both the cohort given TCH (92% vs. 92%) and the cohort given FEC (91% vs. 89%).

In the trial population overall, addition of bevacizumab to chemotherapy tripled the rate of all grade 3/4 adverse events of special interest (27% vs. 8%, P less than .0001), such as hypertension, congestive heart failure, and gastrointestinal perforation.

Dr. Slamon disclosed that he serves as an adviser to Roche/Genentech, which supported the trial.