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Gene signature may improve prognostication in ovarian cancer
The 101-gene expression signature, called OTTA-SPOT, improved on age and stage in predicting overall survival.
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Incidence, prognosis of second lung cancers support long-term surveillance
A study using SEER data finds that overall survival of surgically resected second primary lung cancers occurring 4-10 years out is similar to that...
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Early screening may halve breast cancer mortality in childhood cancer survivors
A modeling study supports early breast cancer screening in women with a history of chest radiation.
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Trio of antibodies may enable earlier diagnosis of axSpA
The prevalence of autoantibodies to three novel axSpA peptides was more than twice as high among patients with early disease as among patients...
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DECT has mixed performance in differentiating gout vs. CPPD
In a German cohort study of 30 patients, the noninvasive test had high specificity but only moderate to poor sensitivity.
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New registry focuses on rheumatic immune-related AEs of cancer therapy
Data from the German TRheuMa registry suggest these events are generally mild or moderate, verifiable by CRP level and imaging (but not...
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Studies give new insight on starting, stopping etanercept in nonradiographic axSpA
Pfizer-supported trials may help to define the optimal use of etanercept for nonradiographic disease.
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No link seen between methotrexate, interstitial lung disease in RA
Patients with RA had roughly three to five times the risk of interstitial lung disease, compared with the general population, but use of this...
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Some biologics may be better than others for averting anterior uveitis
A Swedish cohort study of more than 3,500 patients with ankylosing spondylitis or undifferentiated spondyloarthritis finds that, relative to other...
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Avacopan notches a win in ANCA-associated vasculitis
The pivotal ADVOCATE trial showed that, relative to prednisone, the oral C5a receptor antagonist yielded a superior rate of sustained remission at...
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Blood test might detect multiple cancer types, study suggests
The test, which uses methylation patterns in plasma cell-free DNA, had specificity and sensitivity approaching those needed for population-based...
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Cardiovascular disease is implicated in link between air pollution and dementia
The Swedish SNAC-K study of nearly 3,000 older adults suggests that heart failure and ischemic heart disease enhance the deleterious effect of air...
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CLEOPATRA: Pertuzumab has long-term benefit in HER2+ breast cancer
Adding pertuzumab to trastuzumab and docetaxel as first-line therapy for metastatic HER2-positive breast cancer reduced the risk of death by 31%...
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Live zoster vaccine confers limited protection during tofacitinib therapy
Five percent of patients with rheumatoid arthritis given the live attenuated zoster vaccine before starting tofacitinib still developed shingles...