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Avacopan notches a win in ANCA-associated vasculitis
The pivotal ADVOCATE trial showed that, relative to prednisone, the oral C5a receptor antagonist yielded a superior rate of sustained remission at...
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Blood test might detect multiple cancer types, study suggests
The test, which uses methylation patterns in plasma cell-free DNA, had specificity and sensitivity approaching those needed for population-based...
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Cardiovascular disease is implicated in link between air pollution and dementia
The Swedish SNAC-K study of nearly 3,000 older adults suggests that heart failure and ischemic heart disease enhance the deleterious effect of air...
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CLEOPATRA: Pertuzumab has long-term benefit in HER2+ breast cancer
Adding pertuzumab to trastuzumab and docetaxel as first-line therapy for metastatic HER2-positive breast cancer reduced the risk of death by 31%...
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Live zoster vaccine confers limited protection during tofacitinib therapy
Five percent of patients with rheumatoid arthritis given the live attenuated zoster vaccine before starting tofacitinib still developed shingles...
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Vision symptoms are common and often life-altering for patients with Parkinson’s disease
Two-thirds of patients reported ophthalmologic problems that were severe enough to interfere with activities such as walking, reading, working on...
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Adjuvant chemo emerges as new standard in upper tract urothelial cancer
The POUT trial suggests platinum-based chemotherapy is safe and effective in this rare disease that lacks international consensus on postsurgical...
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Adjunctive surgery may be unnecessary in many testicular cancer patients
SAN FRANCISCO – Adjunctive resection of organs, blood vessels, or bone was deemed unnecessary in almost 40% of testicular cancer patients analyzed...
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Gene therapy appears effective in bladder cancer patients with few options
SAN FRANCISCO – Intravesical gene therapy produced durable responses in patients with non–muscle invasive bladder cancer that did not respond to...
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Apalutamide benefit sustained in mCSPC regardless of next therapy
SAN FRANCISCO – The risk of second progression-free survival events was about one-third lower for patients who initially received apalutamide...
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Seminoma: Risk-adapted strategy could mean less toxic chemo
SAN FRANCISCO – Findings of the SEMITEP trial suggest that early FDG-PET identifies the two-thirds of men with highly chemosensitive low-volume...
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SBRT may boost efficacy of immunotherapy in renal cell carcinoma
SAN FRANCISCO – More than half of patients in the RADVAX RCC trial had a response in nonirradiated lesions, but the prespecified threshold for...
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Multiomics blood test outperforms others for CRC
SAN FRANCISCO - A multiomics test detected stage I and II colorectal cancer with 94% sensitivity and specificity, outperforming a fecal...
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Hypofractionated radiotherapy for prostate cancer stands the test of time
SAN FRANCISCO – An 8-year update of the CHHiP trial confirms that hypofractionated radiotherapy yields a noninferior rate of freedom from...