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Generalized Vaccinia After Smallpox Vaccination With Concomitant Primary Epstein Barr Virus Infection

A patient presents with a spreading rash 9 days following inoculation with the smallpox vaccine.
Federal Practitioner. 2017 March;34(3):34-36
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Conclusion

The smallpox vaccination is unique among vaccinations. It is the only vaccine that is administered via inoculation with a bifurcated needle, requires regular follow-up care, and can be spread to casual contacts.5

It is important for any practitioner administering the smallpox vaccine to be aware of associated AEs. A greater knowledge of the unique challenges with the smallpox vaccine allows for better patient selection that eliminates those with conditions that impair their immune system and improves patient education.