In our case, histologic examination revealed the characteristic findings of LS, VIN, and SCC in succession. This sequence is evidence of progressive transition from LS to VIN and then to SCC. Consequently, this case suggests that vulvar LS may act as both an initiator and a promoter of carcinogenesis and that VIN may be the direct precursor of vulvar SCC. In conclusion, LS has a considerable risk for malignant transformation and requires continuous follow-up in all patients. Early histological detection of invasive lesions is crucial to reduce the risk for vulvar cancer.
Transition From Lichen Sclerosus to Squamous Cell Carcinoma in a Single Tissue Section
Joung Soo Kim, MD, PhD; Min Won Lee, MD; Jun Oh Paek, MD; Ho Song Kang, MD; Hee Joon Yu, MD, PhD
From the Department of Dermatology, Hanyang University, Guri Hospital, South Korea.
The authors report no conflict of interest.
Correspondence: Hee Joon Yu, MD, PhD, Department of Dermatology, Hanyang University, Guri Hospital, Guri, Gyeonggi-do 471-701, South Korea (email@example.com).