Hedgehog Pathway Inhibitor Helps Fight Cancer

Examining the possibility of acquired resistance to hedgehog pathway inhibitors will be key in future studies, they noted. The potential adverse effects of hedgehog pathway blockade in children must also be delineated, as they are the largest population of patients with medulloblastoma.

Dr. Dlugosz reported receiving consulting fees from Merck & Co. and grant support from Pfizer Inc. Dr. Von Hoff reported receiving clinical research funding from Genentech Inc. Dr. Rudin reported receiving research funding and a BioOncology Grant Program Award from Genentech, as well as a clinical scientist award in translational research from Burroughs Wellcome Fund. Dr. Talpaz had no conflicts to report.