Pain
Reviews
Functional heartburn: An underrecognized cause of PPI-refractory symptoms
Functional heartburn is the most common cause of failure of proton pump inhibitor therapy.
Reviews
Beyond depression: Other uses for tricyclic antidepressants
The pharmacology of these drugs, their potential uses in conditions other than depression, and safety considerations.
From the Editor
Off-label and oft-prescribed
When prescribing drugs for uses beyond their FDA indications, we need to explain their anticipated side effects and benefits.
Reviews
SEEDS for success: Lifestyle management in migraine
Lifestyle counseling can be based on the mnemonic SEEDS: sleep, exercise, eat, diary, and stress.
From the Editor
A few pearls can help prepare the mind
The caregiver with a prepared mind is more likely to experience the diagnostic epiphany.
Medical Grand Rounds
Myopathy for the general internist: Statins and much more
How to evaluate and manage muscle complaints in patients taking a statin, interpret creatine kinase test results, and recognize common as well as...
Editorial
Aspirin: 4,000 years and still learning
What we know about aspirin—and what we still need to learn.
Reviews
Cannabis for peripheral neuropathy: The good, the bad, and the unknown
Even where it is legal, doctors should recommend it only after careful consideration.
Editorial
Cannabis for chronic pain: Not a simple solution
Real concerns include amotivation, worsening psychiatric states, chronic disability, and chemical dependence.
From the Editor
A physician’s response to observational studies of opioid prescribing
Not long ago, we were told we needed to do better at relieving pain.