Prehysterectomy Anemia Ups Transfusion Risk


From the Annual Meeting of the Society of Obstetricians and Gynaecologists of Canada

Major Finding: Women who had anemia preoperatively were ninefold more likely to receive a transfusion than their nonanemic counterparts.

Data Source: A retrospective case-control study of 441 women who underwent hysterectomy for benign conditions.

Disclosures: Dr. Mangel reported that he had no relevant financial disclosures.

VANCOUVER, B.C. – Preoperative anemia sharply increases the odds that women undergoing elective hysterectomy for a benign condition will need a transfusion, according to a study of over 400 women.

In a retrospective cohort study of 441 women, those who were found to be anemic (defined as having a hematocrit of less than 30%) on their preoperative bloodwork were ninefold more likely to receive a transfusion intraoperatively or postoperatively after other factors were taken into account.

“Blood transfusion is a relatively safe intervention in the 21st century, but it's not without risks, such as the risk of infectious transmission or fluid overload, and blood supply is limited. So we don't want to give blood unless we have to give blood,” lead investigator Dr. Jeffrey Mangel commented in an interview.

“Anemia is a modifiable risk factor,” he added. “In a short period of time, you can't change a patient's weight or their prior surgical history or other things, but you certainly can change their preoperative hematocrit.”

For example, physicians can encourage anemic women to begin or better comply with iron therapy and start them on gonadotropin-releasing hormone (GnRH) agonist therapy to halt menstruation. Still, these interventions take approximately 2 to 3 months to restore red blood cell parameters to the normal range.

“The barriers to that might be more along the lines of convenience,” he noted, in that patients and physicians alike have already scheduled and prepared for the surgery. “So there is an element of inconvenience for the patient and the doctor that may prevent people from doing this.”

“But from the quality of care point of view, it's probably at least something that should be offered to patients before they have their surgery,” added Dr. Mangel, who is director of the division of urogynecology and pelvic surgery at MetroHealth Medical Center, and with the reproductive biology department at Case Western Reserve University, both in Cleveland. “Some patients might opt for the increased risk of getting blood if they don't choose to delay their surgery. But if I were advising women who were going to have this type of surgery, I would like them to minimize every possible risk of getting blood if they don't need to get it.”

For the study, he and his colleagues retrospectively queried the MetroHealth electronic medical record system to identify women who underwent an elective hysterectomy for a benign condition between 2000 and 2005. They compared characteristics between 137 women who received a perioperative transfusion and 304 women who did not.

Study results showed that the two groups were similar in terms of age (mean age was 45 years), race, body mass index (mean BMI was 31 kg/m

Many of the women who were transfused were anemic preoperatively (78%), compared with 25% of nonanemic women. The difference corresponded to ninefold higher odds of transfusion in adjusted analyses.

In addition, as might be expected, women were more likely to receive a transfusion if they had a greater estimated blood loss during the surgery. Age, body mass index, and prior history of surgeries did not influence this outcome, he said at the meeting.

Further analyses showed that the odds of transfusion were also higher for women whose indication for surgery was fibroids and/or menorrhagia versus prolapse, and for women having an abdominal hysterectomy versus women who had a transvaginal or laparoscopic procedure.

In the case of menorrhagia, women usually have a known history of anemia, according to Dr. Mangel. But the anemia can be much more severe preoperatively than anticipated, possibly related to a longer time between deciding to have the surgery and actually having it.

There are no formal guidelines when it comes specifically to managing anemia in patients undergoing hysterectomy, he said, but a general surgical principle is that the healthier a patient is going into surgery, the better the likelihood of a good outcome.

“I'm not advocating to have a hard and fast guideline published because I do think you need to leave room for patient counseling, discussion of what matters to the patient, and for there to be some physician judgment involved regarding the risks of postponing this person's surgery versus not,” he said. For instance, a patient who is unlikely to return for a rescheduled hysterectomy in 2 to 3 months may get into an emergent situation where, ironically, she needs a transfusion.


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