Impaired Dopaminergic Neurotransmission Is Observed in Dystonia Gene Carriers
Neurology Reviews. 2009 October;17(10):16
October 1, 2009|Neurology Reviews
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Increased synaptic dopamine levels and dysfunction or loss of D2-bearing neurons are associated with reduced D2 receptor availability in dystonia gene carriers. This may represent a permissive factor for primary dystonia.