Multiple Sclerosis
Literature Review
Serum levels of neurofilament light are increased before clinical onset of MS
The findings support the existence of a prodromal phase of MS and could facilitate early diagnosis and treatment.
From the Journals
Modafinil use in pregnancy tied to congenital malformations
A large Nordic study confirms a safety signal seen in postmarketing surveillance.
From the Journals
Medicaid spending on MS drugs rose despite introduction of generic glatiramer
“Although some of this increase is attributable to the 2014 Medicaid expansion, the primary driver was rising DMT costs per prescription, which...
News from the FDA/CDC
First generics for Gilenya approved by FDA
Approvals for fingolimod generics were issued to three companies.
Conference Coverage
Late-onset MS is often more severe than earlier-onset MS
ST. LOUIS – Late-onset MS often has faster accrual of disability and might require different treatment options.
Conference Coverage
MS-related disability may be decreasing
STOCKHOLM – International data indicate that the prognosis of MS has improved, partly as a result of treatment.
News from the FDA/CDC
FDA approves diroximel fumarate for relapsing MS
The oral drug, marketed as Vumerity, converts to the same active metabolite as dimethyl fumarate.
Conference Coverage
Adolescent lung inflammation may trigger later MS
STOCKHOLM – Swedish national health care registry studies show associations between pneumonia or infectious mononucleosis occurring in early...
Conference Coverage
Smoking impairs cognition and shrinks brain volume in MS
STOCKHOLM – New evidence suggests the damage may be partially reversible.
Conference Coverage
In patients with CIS, combined omics predicts conversion to clinically definite MS
STOCKHOLM – Oligoclonal band status is helpful for diagnosis, but cannot predict who will go on to develop clinically definite MS.
Conference Coverage
Investigators use ARMSS score to predict future MS-related disability
STOCKHOLM – The score is the basis for a measurement that is stable over time.