Gout exacerbation, weakness, hypotension—Dx?
The Journal of Family Practice. 2014 August;63(8):455-456
August 1, 2014|The Journal of Family Practice
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Our patient died on hospital Day 7. Contributing factors included premorbid immunosuppression, renal insufficiency, and concomitant P-glycoprotein and CYP3A4 inhibition.
THE TAKEAWAY
Colchicine toxicity from therapeutic doses may occur in patients taking concomitant immunosuppressive drugs. Physicians who prescribe colchicine should be aware of these additional risks and adjust dosages accordingly. Activated charcoal can be given for acute overdose.
