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Doubt Cast on Major Role for PFO Closure in Cryptogenic Stroke

Author and Disclosure Information
Multiple Flaws Make CLOSURE I Results Misleading

FROM THE ANNUAL SCIENTIFIC SESSIONS OF THE AMERICAN HEART ASSOCIATION

The CLOSURE I study was sponsored by NMT Medical, which markets the STARFlex closure device. Dr. Furlan said that he is a consultant to NMT Medical and was the principal investigator for the trial. Dr. Amarenco said that he has received research grants from Sanofi-Aventis, Bristol-Myers Squibb, AstraZeneca, Merck, and Pfizer.