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High adverse events with TB prevention in HIV-infected pregnant women

 

Key clinical point: Immediate tuberculosis prevention therapy with isoniazid (IPT) during pregnancy was associated with more adverse pregnancy outcomes than delayed IPT.

Major finding: The rate of adverse pregnancy outcomes was 23% with immediate IPT during pregnancy versus 17% for IPT delayed until 12 weeks postpartum (P =. 009).

Data source: Randomized trial in 156 HIV-infected pregnant women in seven countries that have high TB prevalence rates.

Disclosures: The study was sponsored by the U.S. National Institutes of Health. Dr. Gupta reported having nothing to disclose.

Source: Gupta A et al. CROI 2018, Abstract Number 142LB.


 

FROM CROI 2018

“I think we now need to reweigh the evidence for pros and cons for IPT in pregnancy,” Dr. Gupta concluded.

The study was sponsored the National Institutes of Health. Dr. Gupta reported having nothing to disclose.

SOURCE: Gupta A et al. CROI 2018, Abstract Number 142LB.

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