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Pexidartinib gets ODAC nod for tenosynovial giant cell tumor treatment
Missing efficacy data from the pivotal ENLIVEN trial and adverse liver events were points of contention.
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FDA panel not ready to recommend quizartinib approval for FLT3-ITD+ AML
SILVER SPRING, MD. – A small clinical benefit, questions about the validity of the data, and concerns about cardiovascular adverse events point to...
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High pCR rate in HPV+ HNSCC with nivolumab/SBRT
ATLANTA – Nine of 10 patients in a phase 1/1b trial had pathologic complete responses to neoadjuvant nivolumab and radiation.
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Subcutaneous or IV trastuzumab? Take your pick
Long-term follow-up of women with early, HER2-positive breast cancer showed similar efficacy and safety for subcutaneous or intravenous...
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Quality of life decrement with salvage ASCT is short-lived
Salvage stem cell transplant in patients with multiple myeloma was linked to short-term, but not long-term, declines in quality of life, compared...
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RIT consolidation may be an option for unfit MCL patients
Patients who could not undergo transplants had high rates of complete responses to radioimmunotherapy consolidation following induction...
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Adding MET TKI may overcome NSCLC resistance
ATLANTA – Combining the investigational MET inhibitor savolitinib to osimertinib was associated with responses in NSCLC resistant to EGFR-targeted...
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Gilteritinib prolonged survival in FLT3-mutated AML
Patients with acute myeloid leukemia and FLT3-activating mutations are at increased risk for early relapse and poor overall survival.
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MET/MEK inhibitor duo shows activity in resistant NSCLC
ATLANTA – About one-third of patients with heavily pretreated non–small cell lung cancer had responses to osimertinib and selumetinib.
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CAR T cells home in on HER2 in advanced sarcomas
ATLANTA – A teenage girl with advanced osteosarcoma has had a durable complete remission after receiving CAR T cells targeted to HER2.
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Novel chemo/PARP inhibitor strategy promising for advanced pancreatic cancer
ATLANTA – Investigators are treating patients with advanced pancreatic cancer and homologous recombination deficiencies with a novel strategy of...
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Genetic variant increases stroke risk in childhood cancer survivors
ATLANTA - Dr. Yadav Sapkota of St. Jude Children's Research Hospital discusses the identification of a genetic variant that is strongly associated...
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Anti-EGFR TKI, MET inhibitor team up against drug-resistant NSCLC
ATLANTA – Dr. Lecia Sequist discusses early results from the TATTON trial, which is evaluating osimertinib plus...
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CAR T cells target HER2 expression in advanced sarcomas
ATLANTA – Although HER2 expression in osteosarcoma and rhabomyosarcoma is too low for HER2-targeted therapies such...
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Anastrozole/fulvestrant prolongs OS in metastatic ER+ breast cancer
Women with no prior tamoxifen exposure benefited most from the combination, compared with those receiving anastrozole alone.