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Pembrolizumab plus chemo boosts pCR rate in TNBC
SAN ANTONIO – The immune checkpoint inhibitor added to standard chemotherapy increased the likelihood of a pathologic complete remission,...
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Sutimlimab boosts hemoglobin, quality of life in cold agglutinin disease
ORLANDO – A novel antibody targeted to the complement pathway increased hemoglobin and improved quality of life in patients with cold agglutinin...
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Trastuzumab deruxtecan has good activity in advanced HER2-positive breast cancer
SAN ANTONIO – The overall response rate was 61% in heavily pretreated patients, but interstitial lung disease was a major side effect of the...
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Failed ATEMPT: T-DM1 no safer in early HER2+ breast cancer
SAN ANTONIO – The incidence of clinically relevant toxicity was similar between trastuzumab emtansine and...
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Care coordination, equity can eliminate disparities for nonwhite patients with DLBCL
The use of a nurse navigation program to facilitate care helped iron out racial disparities that could lead to poor outcomes.
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High complete response rate seen with novel CAR-T for myeloma
ORLANDO – A CAR T product targeting B-cell maturation antigen, one of several in development, was associated with a 100% overall response rate.
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Bilateral mastectomy reduces second breast cancer risk, but not deaths
The risk of second contralateral breast cancer is low regardless of primary breast cancer therapy, results of a retrospective study show.
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Survival gains in HR+/HER2– MBC trials yet to be seen in real world
The introduction of nine new systemic adjuvant therapies did not change survival outcomes for patients with HR+/HER2- metastatic breast cancer.
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Single-fraction radiation just misses mark for spinal compression relief
The primary noninferiority endpoint was not met, but a small difference between single- and multi-fraction radiation may not be clinically...
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Transfusion-related lung injury is on the rise in elderly patients
SAN ANTONIO – Researchers at the Food and Drug Administration examined trends in potentially life-threatening or fatal transfusion-related adverse...
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Cancer pain management inadequate in opioid-saturated areas
Less than one-fourth of cancer patients in rural southwest Virginia received prescription opioids, suggesting suboptimal pain management.
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Getting high heightens stroke, arrhythmia risks
Cannabis use or abuse among the young was associated with adverse cardiovascular consequences in two studies.
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Best practice alerts really can work
SAN ANTONIO – A majority of alerts triggered by red blood cell orders were overridden, but for sound clinical reasons, investigators found.
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First NCCN guideline on hematopoietic cell transplantation focuses on GVHD
Diagnosis and management of both acute and chronic graft-versus-host disease is at the core of the recommendations.