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MAIA: Daratumumab plus len-dex improves myeloma PFS
SAN DIEGO – Adding the anti-CD38 monoclonal antibody to lenalidomide and dexamethasone significantly decreased 30-month risk of progression.
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CTC counts signal treatment choice in ER-positive/HER2-negative metastatic breast cancer
SAN ANTONIO – Circulating tumor cell counts rival clinician choice for determining whether to prescribe hormonal therapy or chemotherapy,...
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DTCs in marrow herald worse outcomes for early breast cancer
SAN ANTONIO – Disseminated tumor cells detected in marrow at diagnosis or primary surgery for early breast cancer are associated with worse...
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Ibrutinib-rituximab ‘new standard of care’ in younger CLL patients
SAN DIEGO – Survival and safety outcomes were better with ibrutinib and rituximab than with the FCR regimen.
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Tamoxifen at 5 mg halves recurrence of breast intraepithelial neoplasia
SAN ANTONIO – For patients with ADH, DCIS, or LCIS, one-fourth of the standard dose reduced risk for both invasive disease/DCIS and contralateral...
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Mutation confers resistance to venetoclax in CLL
SAN DIEGO—A recurrent mutation in BCL2, the therapeutic target of venetoclax, appears to be a major contributor to drug resistance in patients...
Video
CTC matches MD judgment for mBC therapeutic choice
SAN ANTONIO – For patients with ER-positive, HER2-negative metastatic breast cancer, the use of CTC counts can help clinicians decide between...
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Low-dose tamoxifen halves recurrence of breast intraepithelial neoplasia
SAN ANTONIO – Women with breast intraepithelial neoplasms who took tamoxifen for 3 years at a dose of 5 mg per day had a 50% reduction in risk of...
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Adjuvant T-DM1 halves HER2-positive invasive breast cancer recurrence
SAN ANTONIO – The 3-year invasive disease-free recurrence was 88.3% for patients with residual disease treated with T-DM1 versus 77.0% with...
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CLL resistance mechanism to venetoclax identified
SAN DIEGO – The mutation was present only after therapy in paired samples from patients enrolled in clinical trials of venetoclax.
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KATHERINE: T-DM1 doubles HER2-positive invasive disease-free survival
SAN ANTONIO – For the primary endpoint of invasive disease-free survival, T-DM1 was associated with a hazard ratio of 0.50.
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In IDH-mutated AML, first-line IDH inhibitors plus chemo may boost remission
SAN DIEGO – Minimal residual disease and mutational clearance were seen in a significant proportion of patients.
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Shorter R-CHOP regimen noninferior in certain DLBCL patients
SAN DIEGO—A shortened regimen of four cycles of rituximab (R) plus cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy...
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Update shows durable responses in rel/ref DLBCL
SAN DIEGO—An updated analysis of the JULIET trial showed that tisagenlecleucel produced a high rate of durable responses in adults with relapsed...
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JULIET: CAR T cells go the distance in r/r DLBCL
SAN DIEGO – Median overall survival among patients with complete responses to CAR-T cell therapy in the JULIET trial has not been reached.