Secondary primary malignancies are common in HCC

Key clinical point: Risk factors for secondary primary malignancies in HCC patients included older age at diagnosis, localized disease, smaller tumor size, and treatment with local tumor destruction, hepatectomy, and transplantation.   

Major finding: A total of 1,593 HCC patients (3.95%) developed secondary primary malignancies starting at 2 months after their initial HCC diagnoses; the top five sites were lung and bronchus; prostate, non-hodgkin lymphoma, colon, and breast.

Study details: The data come from a retrospective study of 40,314 adults with hepatocellular carcinoma who were diagnosed between 2000 and 2014 and identified through the SEER database who were followed for a median of 19 months from their initial HCC diagnoses.

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Disclosures: The study was supported by the National Natural Science Foundation of China. The researchers had no financial conflicts to disclose.

Source: Kong J et al. Front Oncol. 2021 Aug 23. doi: 10.3389/fonc.2021.713637.