MicroRNA-889 overexpression predicts poor prognosis in HCC

Key clinical point: HCC patients with a higher expression of microRNA-889 had lower overall survival rates compared to those with low expression of miR-889.

Major finding: Overexpression of miR-889 significantly increased HCC cell proliferation, migration, and invasion in HCC cell lines, and overall survival was lower in the high expression of miR-889 (P = 0.013).

Study details: The data come from analysis of 113 fresh specimens of HCC and para-cancerous benign tissue from 113 patients with HCC who underwent partial or total hepatectomy between January 2010 and June 2015 at a single center.

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Disclosures: The study received no outside funding. The researchers had no financial conflicts to disclose.  

Source: Wang H et al. Diagn Pathol. 2021 Jun 11. doi: 10.1186/s13000-021-01111-5.