Cognitive function remains a concern with ADT treatment for prostate cancer

Key clinical point: Approximately half of the studies (16) in a systematic review showed no association between androgen deprivation therapy and reduced cognitive function in prostate cancer patients; however, 11 of the 31 studies showed a negative effect on cognitive functioning.

Major finding: A total of 18 studies used a prospective design to assess the impact of androgen deprivation therapy on cognitive function, totaling 968 individuals. Of these, 9 studies showed no significant effect of ADT on cognitive function.

Study details: The data come from a systematic review of 31 studies published up to February 2020.

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Disclosures: The study received no outside funding. The researchers had no financial conflicts to disclose.

Source: Andela CD et al. Int J Urol. 2021 Jun 14.  doi: 10.1111/iju.14596.