Key clinical point : Gene mutations involving ASXL1 were significantly associated with increased risk of vascular events in adults with myelodysplastic syndrome, but Trisomy 8 appeared to have a protective effect.
Major finding : Overall, the incidence of vascular disease in the study population was 27%; mutations in the ASXL1 in particular were significant predictors of vascular disease in multivariate analysis (odds ratio 4.2); however, both elevated ferritin and Trisomy 8 were significantly associated with a lower risk of vascular disease in low-risk MDS patients ( P = .043 and P = .036, respectively).
Study details : The data come from a retrospective analysis of 236 MDS patients aged 18 years and older who were seen and treated at a single center between 2010 and 2018.
Disclosures: The study received no outside funding. The researchers had no financial conflicts to disclose.
Citation: Faber MG et al. eJHaem. 2020 Sept 28. doi: 10.1002/jha2.101.