Clinical Review

Open Clinical Trials for Patients With Multiple Sclerosis


Providing access to clinical trials for veteran and active-duty military patients can be a challenge, but a significant number of trials are now recruiting patients from those patient populations. More than 51,000 open trials are listed on the website. Many explicitly recruit patients from the VA (212 studies), the military (132 studies), and IHS and native health organizations (4 studies). The VA Health Services Research and Development department alone sponsors > 250 research initiatives, and many more are sponsored by Walter Reed National Medical Center and other major defense and VA facilities. The clinical trials listed below are all open as of February 22, 2017, and are focused on the treatment of multiple sclerosis (MS) and other neurologic disorders. For additional information and full inclusion/exclusion criteria, please consult

Integrating Caregiver Support Into MS Care (MS Caregiver)

With loss of mobility in MS comes an increase in amount and types of caregiver assistance, with a concomitant increase in burden for the caregiver. This feasibility study will test integration of a successful behavioral caregiving intervention into clinical practice to improve functioning of veterans with MS and their caregivers. Caregivers of veterans with MS will receive a behavioral caregiver intervention designed to address caregiver coping and management of patient concerns, with special focus on patient mobility and walking. A pre-post intervention design will compare outcomes for veterans and caregivers.

ID: NCT02835677
Sponsor: Memphis VA Medical Center
Contact: Linda O. Nichols, PhD,, Jennifer L. Martindale-Adams,

Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis

Primary fatigue represents a major cause of disability in patients with MS, being reported in about 90% of cases. The investigators propose a characteristic eye movement abnormality (internuclear ophthalmoparesis), commonly encountered in MS, as a simple model for primary motor fatigue. The investigators propose a medical treatment to improve ocular performance/fatigue in internuclear ophthalmoparesis, which can reduce visual disability and improve quality of life in veterans with MS.

ID: NCT02391961
Sponsor: VA Office of Research and Development
Location (contact): Louis Stokes VA Medical Center, Cleveland, Ohio (Holly B. Henry)

Dysport Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity Due to Spinal Cord Injury or Multiple Sclerosis

The purpose of this study is to provide confirmatory evidence of the safety and efficacy of 2 Dysport (AbobotulinumtoxinA) doses (600 units [U] and 800 U), compared to placebo in reducing urinary incontinence in adult subjects treated for neurogenic detrusor overactivity due to spinal cord injury or MS.

ID: NCT02660138
Sponsor: Ipsen
Location (contact Ipsen Recruitment Enquiries, clinical.trials@ VA Long Beach Healthcare System, California, VA Palo Alto Health Care System, California, Raymond G. Murphy VAMC Albuquerque, New Mexico, Louis Stokes Cleveland Veterans Affairs Medical Center, Ohio.

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