From the Journals

Possible increased breast cancer risk found in women with schizophrenia

 

Key clinical point: Women diagnosed with schizophrenia should receive intensive screening and treatment for breast cancer.

Major finding: Women with schizophrenia showed a 31% higher standardized incidence ratio of breast cancer than that of the general population.

Data source: Meta-analysis of 12 cohort studies involving 125,760 women.

Disclosures: The Tianjin Health Bureau Foundation and the Natural Science Foundation of Tianjin, China, supported the work. No conflicts of interest were declared.

Source: Zhuo C et al. JAMA Psychiatry. 2018 Mar 7. doi: 10.1001/jamapsychiatry.2017.4748.


 

FROM JAMA PSYCHIATRY

A meta-analysis has found an increased risk of breast cancer in women with schizophrenia, but its authors noted significant diversity of results across the included studies.

In the meta-analysis, Chuanjun Zhuo, MD, PhD, and Patrick Todd Triplett, MD, presented the results of 12 cohort studies involving 125,760 women that showed the risk of breast cancer in women with schizophrenia, compared with the general population.

They found that women with schizophrenia had a 31% higher standardized incidence ratio of breast cancer (95% confidence interval, 1.14-1.50; P less than .001). However, significant heterogeneity was found between studies, with the prediction interval ranging from 0.81 to 2.10. The report was published in JAMA Psychiatry.

“Accordingly, it is possible that a future study will show a decreased breast cancer risk in women with schizophrenia compared with the general population,” said Dr. Zhuo of Tianjin Medical University, China, and Dr. Triplett, of Johns Hopkins University, Baltimore.

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