Genetic Pathways, Part 1
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As part of our commitment to resident education, Cutis is excited to offer this monthly section with board-relevant, easy-to-review material.
This fact sheet details some of the important pathways in dermatology and the clinical manifestations seen with these genetic derangements.
4. A female neonate aged 2 weeks presented with linear and whorled vesicles on the thighs and trunk. The delivery was uncomplicated. The patient was afebrile, but her mother said she has been “doing well” at home. On pathology, what do you expect to see?
a. apoptosis of epidermal cells
b. cell-poor blister
,c. molding and margination of chromatin as well as multinucleated giant cells
d. numerous pseudohyphae
e. spongiosis of epidermal cells