Genetic Pathways, Part 1
August 18, 2015|Cutis
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As part of our commitment to resident education, Cutis is excited to offer this monthly section with board-relevant, easy-to-review material.
This fact sheet details some of the important pathways in dermatology and the clinical manifestations seen with these genetic derangements.
5. A young child presents with linear atrophic plaques with fat herniation and raspberrylike oral papillomas. What signal transduction pathway is altered in this syndrome?
a. ABCA12 (ATP-binding cassette, sub-family A, member 12)
b. adenylate cyclase
,c. ß-catenin
d. LEKTI (lympho-epithelial Kazal-type-related inhibitor)
e. nuclear factor κ light chain enhancer of activated B cells
The answers appear on the next page.
