Weight gain with antipsychotics: What role does leptin play?
Might antipsychotics disturb the appetite-suppressing effects of this hormone?
Medications such as olanzapine and clozapine carry substantial metabolic burdens but are effective treatments for some patients who do not respond to other antipsychotics. Elucidating mechanisms by which antipsychotic medications affect metabolic parameters remains important for:
- quantifying patient risk
- informing the frequency and targets of metabolic monitoring during antipsychotic therapy
- permitting the development of novel agents without these limitations.
Related resource
- Leucht S, Corves C, Arbter D, et al. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet. 2009;373(9657):31-41.
Drug brand names
- Amantadine • Symmetrel
- Aripiprazole • Abilify
- Clozapine • Clozaril
- Haloperidol • Haldol
- Nizatidine • Axid
- Olanzapine • Zyprexa
- Quetiapine • Seroquel
- Risperidone • Risperdal
- Ziprasidone • Geodon
Disclosures
Dr. Jin receives grant/research support from the National Institutes of Health, the National Institute of Mental Health, Otsuka Pharmaceuticals, and the Stanley Medical Research Foundation. He is a consultant to the Stanley Medical Research Foundation.
Dr. Meyer receives grant/research support from Bristol-Myers Squibb, the National Institutes of Health, the National Institute of Mental Health, and Pfizer Inc. He is a consultant to Bristol-Myers Squibb, Janssen Pharmaceutica, Organon USA (now Merck), Pfizer Inc., Vanda Pharmaceuticals, and Wyeth Pharmaceuticals (now Pfizer Inc.) and a speaker for AstraZeneca, Bristol-Myers Squibb, Dainippon Sumitomo Pharma, and Pfizer Inc.
