Do cholinesterase inhibitors enhance cognition in schizophrenia?

• when other adjuncts have failed
  
• as a supplement to other augmentation strategies, such as cognitive-behavioral therapy or family therapy.
  

• Mohamed S, Paulsen JS, O’Leary D, et al. Generalized cognitive deficits in schizophrenia. Arch Gen Psychiatry 1999;56:749-54.
  
• Risch SC, Horner MD, McGurk S, et al. Double-blind donepezil-placebo crossover augmentation study of atypical antipsychotics in chronic, stable schizophrenia: a pilot study. Schizophr Res 2007;93:131-5.
  

• Donepezil • Aricept
  
• Rivastigmine • Exelon
  
• Galantamine • Reminyl, Razadyne
  
• Ziprasidone • Geodon
  

Dr. Risch receives research support from the National Institute of Mental Health, Abbott Laboratories, GlaxoSmithKline, Bristol-Myers Squibb, and Forest Pharmaceuticals. He is a consultant to and speaker for AstraZeneca and Pfizer Inc.