Pharmacogenomic DNA chip
Test anticipates adverse response to medication.
While I believe the test’s usefulness will soon be widely understood, courses are available to help clinicians learn about genetic testing. Mayo Clinic College of Medicine (https://www.mayo. edu/cme/genomics.html) offers an annual week-long CME course in August. The American Psychiatric Association, as part of its May 2006 annual meeting, will offer a similar half-day course led by Mayo Clinic psychiatrists.
Cost. The exact cost of using the pharmacogenomic chip varies, as each laboratory sets fees for genotyping. Even so, genotyping could offer enormous cost savings by preventing failed medication trials and reducing the need for more-intensive psychiatric care. Furthermore, many insurance companies cover genotype testing.
Related resources
- Pharmacogenomic diagnostic DNA chip product information. www.rochediagnostics.com/products_services/amplichip_cyp450.html.
- Kirchheiner J, Borsen K, Dahl ML, et al. CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages. Acta Psychiatr Scand 2001;103(3):173-92.
Drug brand names
- Amitriptyline • Elavil
- Atomoxetine • Strattera
- Citalopram • Celexa
- Clomipramine • Anafranil
- Desipramine • Norpramin
- Diazepam • Valium
- Escitalopram • Lexapro
- Fluoxetine • Prozac
- Fluphenazine • Prolixin
- Nortriptyline • Pamelor
- Paroxetine • Paxil
- Perphenazine • Trilafon
- Risperidone • Risperdal
Disclosure
Dr. Mrazek is a consultant to Predix Pharmaceuticals.
