Where to find guidance on using pharmacogenomics in psychiatric practice
Genetic-based therapy minimizes the risk of treatment failure and adverse effects.
PharmGKB
Providing searchable annotations of pharmacogenetic variants, PharmGKB summarizes the clinical implications of important pharmacogenes, and includes FDA drug labels containing pharmacogenomics information (https://www.pharmgkb.org).2 The Web site also provides users with evidence-based figures illustrating the pharmacokinetic and pharmacodynamic pathways of drugs that have pharmacogenetic implications.
PharmGKB is an excellent resource to consult for a summary of available evidence when a CPIC guideline does not exist for a given gene or drug.
Other resources
Table 23-8 lists other online resources for practitioners to aid in advancing pharmacogenomics knowledge as it relates to practice.
Putting guidance to best use
Familiarity with resources such as CPIC guidelines and PharmGKB can help ensure that patients with pharmacogenetic test results receive genetically tailored therapy that is more likely to be effective and less likely to cause adverse effects.9,10
