Caleb Rans

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Past donor pregnancy, sex do not affect transfusion-related mortality

Author:: Caleb Rans

Publish date: June 11, 2019

A retrospective analysis of more than 1 million red blood cell transfusion recipients found that there was no significant increase in mortality bas...

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ASCO clinical practice guideline update incorporates Oncotype DX

Author:: Caleb Rans

Publish date: June 4, 2019

In women with hormone receptor–positive, axillary node–negative breast cancer with Oncotype DX recurrence scores of less than 26, there is minimal ...

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NCCN publishes pediatric ALL guidelines

Author:: Caleb Rans

Publish date: June 3, 2019

While treatment for ALL often includes long-term chemotherapy regimens, various types of immunotherapy and targeted therapy are also summarized in ...

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Cediranib may alter DNA repair capacity

Author:: Caleb Rans

Publish date: June 3, 2019

The preclinical finding may have implications for the development of combination treatment with olaparib for cancer patients.

News

Novel anti-PD-1 antibody can be given subcutaneously

Author:: Caleb Rans

Publish date: May 31, 2019

“Subcutaneous administration of an anti-PD-1 antibody in patients with advanced solid tumors appears to be feasible,” the investigators wrote.

News

Revascularization plus exercise is most effective for intermittent claudication

Author:: Caleb Rans

Publish date: May 29, 2019

Percutaneous transluminal angioplasty plus supervised treadmill exercise therapy could be a first-line treatment ...

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Genetic analysis identifies prognostic markers in CLL

Author:: Caleb Rans

Publish date: May 28, 2019

A single 11q22 deletion, lacking an ATM mutation on the other allele, had the shortest progression-free survival among patients with CLL who were t...

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FVIII/W ratio may help predict relapse in hemophilia A

Author:: Caleb Rans

Publish date: May 22, 2019

The biological marker was the first indication of relapse in most patients who relapsed during the study period.

News

Novel chromogenic assay looks accurate in hemophilia A diagnosis

Author:: Caleb Rans

Publish date: May 22, 2019

The BIOPHEN FVIII:C assay had limited variation and performed well when compared with a one-stage clotting assay and another chromogenic assay, the...

News

Low-dose FVIII prophylaxis reduced bleeding in hemophilia A

Author:: Caleb Rans

Publish date: May 22, 2019

Low-dose prophylaxis with factor VIII outperformed on-demand treatment in children with severe hemophilia A. The findings have implications for low...

News

Family history plays a large role in bleeding disorder diagnosis in women

Author:: Caleb Rans

Publish date: May 17, 2019

The survey of women with congenital bleeding disorders in Europe highlighted delays in diagnosis and burdens on activities of daily living.

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CD23 expression linked to improved survival in MCL

Author:: Caleb Rans

Publish date: May 17, 2019

Researchers found that mantle cell lymphoma cases that were CD23 positive had a higher frequency of leukemic nonnodal presentation and CD200 expres...

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Literature review shows inconsistent measurement of financial toxicity

Author:: Caleb Rans

Publish date: May 16, 2019

Systematic review reveals lack of validated instruments to effectively measure the financial burden experienced by cancer patients.

News

Younger patients with NSCLC tend to live longer

Author:: Caleb Rans

Publish date: May 15, 2019

According to a retrospective analysis, younger patients with NSCLC had better survival, despite higher rates of brain metastasis and drive mutation...

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Most postapproval trials explore novel indications

Author:: Caleb Rans

Publish date: May 10, 2019

Among 600 post-approval studies, only 12.0% solely examined the original therapeutic indication.