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Single-fraction spine stereotactic radiosurgery is cost-efficient
Investigators quantified institutional costs associated with radiation treatment options for spinal metastases and found single-fraction...
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SOX11 shows value as diagnostic marker in MCL
The meta-analysis evaluated the diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma.
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Glucocorticoids linked to damage accrual in SLE regardless of disease activity
“These findings suggest that unnecessary use of glucocorticoids should be avoided in the management of the disease where possible,” study authors...
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Frontline ibrutinib saves money over chemoimmunotherapy
An analysis of claims data for more than 1,000 patients with chronic lymphocytic leukemia shows that ibrutinib monotherapy is a less expensive...
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Early lenalidomide may delay progression of smoldering myeloma
Researchers said the findings from the phase 3 study support early treatment as the new standard of care in patients with high-risk smoldering...
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Study detects lower CV risk in breast cancer survivors
At time of first myocardial infarction, those with a breast cancer history were older, had fewer risk factors, and ultimately had better outcomes...
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Lorlatinib induces deep responses in ROS1-positive NSCLC
Among 40 crizotinib-pretreated patients, 14 patients (35%) had an objective response on lorlatinib, with a median duration of response of 13.8...
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Caspofungin bests fluconazole for antifungal prophylaxis in young AML patients
The study suggests that caspofungin is a viable option for prophylaxis against invasive fungal disease in children and young adults with acute...
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Levofloxacin prophylaxis improves survival in newly diagnosed myeloma
Levofloxacin looks like a promising addition to therapy, but the researchers cautioned that antibiotic resistance must be considered.
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Adding pertuzumab shows benefit in ERBB2-positive breast cancer
Total pathologic complete response rates were significantly higher for patients in the pertuzumab arm (39.3%) compared with the placebo arm (21.8...
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MMS linked with better survival in early-stage melanoma
Patients who underwent Mohs micrographic surgery had moderately better survival, compared with those who were treated with wide margin excision....
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SEER analysis reveals medication adherence factors in newly diagnosed myeloma
The study found that more than a third of older patients with multiple myeloma had poor adherence to lenalidomide.
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Pembrolizumab shows promise for relapsed/refractory PMBCL
The findings raise the question of whether PD-1 blockade could resensitize tumors to chemotherapy.
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Exercise intolerance linked to neurocognitive dysfunction in ALL
More study is needed to determine whether increasing exercise capacity would improve neurocognitive outcomes for childhood survivors of acute...
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Ibrutinib linked to hypertension in B-cell malignancies
New or worsening hypertension was also linked with a greater risk of major adverse cardiac events.