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Neratinib in combo with T-DM1 shows promise for advanced HER2+ breast cancer
Responses were most durable in patients with cell-free DNA ERBB2 amplification.
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Extended half-life products cut infusions in Europe
A survey of 33 hemophilia centers showed that the use of extended half-life factor VIII and factor IX products dropped infusions by at least 30%...
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Quercetin may reduce iron overload in beta-thalassemia major
Quercetin is part of the flavone family that exists mainly in apples, berries, onions, tea, and red wine.
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Novel conditioning regimen shows benefit for beta-thalassemia major
The transplant regimen significantly reduced graft-versus-host disease following unrelated-donor hematopoietic stem cell transplant.
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Perceived discrimination linked to delay in ovarian cancer diagnosis for black women
In a case-control analysis, researchers found that every 1-unit rise in the frequency of everyday discrimination was associated with a higher...
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Nivolumab yields long-term survival benefit in advanced NSCLC
In a pooled analysis of four studies, the 4-year overall survival with nivolumab was 14%, compared with historical data demonstrating overall...
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Obinutuzumab-lenalidomide combo shows promise in relapsed/refractory FL
In the phase 2 GALEN study, induction with obinutuzumab and lenalidomide followed by maintenance therapy with obinutuzumab appears effective for...
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Brentuximab vedotin plus nivolumab shows positive outcomes in PMBL
The CheckMate 436 study showed that the combination may be synergistic and is highly active in relapsed/refractory primary mediastinal B-cell...
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Lower BMD found in patients with severe hemophilia A
The decrease in BMD was correlated with reduced functional ability and body mass index, and vitamin D insufficiency or deficiency.
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Hematuria is highly prevalent in pediatric hemophilia A and B
Hematuria was detected in nearly half of children with hemophilia during screening urinalysis.
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Concomitant emicizumab, ITI shows promise in severe hemophilia A
A small case series of pediatric patients with hemophilia A demonstrates the feasibility of using immune tolerance induction for inhibitor...
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Self-reported adherence fails to line up with objective measures in hemophilia
Social desirability bias may be playing a role in patients with hemophilia reporting better adherence than is measured through objective reports...
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Survey: PCI use has declined in ES-SCLC
It appears that, following a study showing little benefit over monitoring with MRI, prophylactic cranial irradiation use has dropped by 28...
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Immune-related toxicities, hospitalization common with checkpoint inhibitor therapy
The most common immune-related adverse events warranting hospital admission were pneumonitis and colitis.
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Cardiovascular complications most common with carfilzomib in relapsed myeloma
For patients taking carfilzomib-based therapy, the most common complications were heart failure, followed by grade 3 or 4 hypertension.