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Comparison shows tighter treat-to-target approach provides better outcomes in RA
Stricter criteria for achieving remission led to a higher likelihood of reaching it when treat-to-target protocols were employed.
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Irinotecan shows promise for triple-negative breast cancer
Irinotecan produced responses in patient-derived xenograft models of triple-negative breast cancer.
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Variants in common genes linked to endometrial cancer risk
Researchers identified 24 single-nucleotide polymorphisms – in genes that play roles in transcriptional regulation, cell survival, and estrogen...
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Number of sexual partners linked to cancer risk
People with 10 or more sexual partners in their lifetime had a greater risk of cancer than people with 0-1 lifetime sexual partners.
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Proteogenomics provides molecular insights into endometrial carcinoma
Analyses have revealed potential therapeutic targets and methods of optimizing therapy for endometrial carcinoma.
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Genetic testing helps avoid false hemoglobinopathy diagnoses in newborns
“We now perform simultaneous protein-based and genetic testing as our standard clinical practice.”
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Preoperative CT shows little value in early vulvar SCC
There was no significant difference in survival or groin node recurrence between patients who underwent preoperative CT and patients who did not...
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Ovarian cancer survival varies between high-income countries
The 3-year net survival was highest in Norway and lowest in Ireland.
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Novel mutations contribute to progression of venetoclax-treated CLL
In comparison to wild-type aspartic acid, the BCL2 Asp103Glu substitution was linked to an approximate 20-fold reduction in affinity for...
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Medical scribe use linked to lower physician burnout
Physicians with a scribe experienced a 12.1% reduction in overall average patient visit duration in an oncology practice.
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New nomogram better predicts bladder cancer risk
In a retrospective analysis of patients who underwent a full microhematuria evaluation, patients with bladder cancer had a higher amount of...
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HRQoL deteriorates during chemoradiotherapy for bladder cancer
However, in an exploratory analysis of 452 patients, health-related quality of life improved to pretreatment levels within 6 months following...
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Adjuvant denosumab falls short in early-stage breast cancer
At 5-year follow-up in the phase 3 D-CARE study, the researchers found no significant difference in bone metastasis-free survival between the...