Article
Kidneys have a lot of nerve
- Author:
- Brian F. Mandell, MD, PhD
Renal denervation shows promise. But hypertension is a heterogeneous condition, and the patient's underlying pathophysiology may dictate the...
Article
Fire, skin, and fat: Inflammation, psoriasis, and cardiovascular disease
- Author:
- Brian F. Mandell, MD, PhD
The connection between psoriasis and atherosclerosis is not well understood, but we should be vigilant about cardiovascular risk factors in these...
Article
Lung cancer screening: One step forward
- Author:
- Brian F. Mandell, MD, PhD
I never expected, perhaps naively, that cancer screening would be so challenging and contentious.
Article
Examine before ordering: An algorithm unchanged by new tests
- Author:
- Brian F. Mandell, MD, PhD
I have always been irked when doctors reflexively order panels of immunologic tests when evaluating patients with "arthritis."
Article
Exploring the human genome, and relearning genetics by necessity
- Author:
- Brian F. Mandell, MD, PhD
The field of medical genetics continues to advance far beyond what many of us were exposed to in medical school.
Article
Talking to patients: Barriers to overcome
- Author:
- Brian F. Mandell, MD, PhD
Not all patients think like doctors, but we need to be able to think like patients.
Article
Bugs, pundits, evolution, and the New Year
- Author:
- Brian F. Mandell, MD, PhD
Pathogens continue to evolve, influenced by human behavior but untouched by partisan dialogue and undaunted by doubting politicians.
Article
Quality, frailty, and common sense
- Author:
- Brian F. Mandell, MD, PhD
Ideal management of a frail older person with severe congestive heart failure is not always about devices and drugs.
Article
The bittersweet of steroid therapy
- Author:
- Brian F. Mandell, MD, PhD
Every physician has had patients with the long-term effects of glucocorticoid therapy, including diabetes.
Article
A discussion of dissection
- Author:
- Brian F. Mandell, MD, PhD
Few medical emergencies are as dramatic as an acutely rupturing aortic aneurysm. Advances in research offer potential for more alternatives to...
Article
When to stop treating the bones
- Author:
- Brian F. Mandell, MD, PhD
Don't let the argument about how long to treat osteoporosis with bisphosphonate drugs stand in the way of initiating therapy in patients at risk...
Article
Out of Morpheus’ embrace
- Author:
- Brian F. Mandell, MD, PhD
We still lack a full understanding of the complex physiology of sleep and the effects of sleep deprivation on a number of clinical conditions,...
Article
When good drugs turn weirdly bad
- Author:
- Brian F. Mandell, MD, PhD
Even the most specific of drugs, such as interferon, can have untoward biologic effects.
Article
The pain of cholesterol-lowering therapy
- Author:
- Brian F. Mandell, MD, PhD
It seems that everyone "knows" that statins cause muscle pain, including many patients with hypercholesterolemia.
Article
Recognizing the unusual: The diagnostic epiphany
- Author:
- Brian F. Mandell, MD, PhD
We have all experienced the sudden recognition of an unexpected diagnosis, such as the case of visceral angioedema due to angiotensin-converting...