Brian F. Mandell, MD, PhD

Article

Gene-based, rational drug-dosing: An evolving, complex opportunity

Author:: Brian F. Mandell, MD, PhD

Publish date: April 1, 2011

Pharmacogenomics promises the opportunity to match the right drug and dose to the right patient. We are not there yet, but the day is coming.

Article

The urge to know: What does iron have to do with infection?

Author:: Brian F. Mandell, MD, PhD

Publish date: March 1, 2011

Why might iron supplementation be harmful in the setting of infection?

Article

Hypertension: Don’t worry about the J curve—treat the patient

Author:: Brian F. Mandell, MD, PhD

Publish date: February 1, 2011

Concerns over being too aggressive remain theoretical. A far greater problem is that we are still not successfully treating hypertension to even a ...

Article

In reply: Gout and chronic kidney disease

Author:: Brian F. Mandell, MD, PhD

Publish date: February 1, 2011

Article

The Journal at 80 years: ‘Same as it ever was’—sort of

Author:: Brian F. Mandell, MD, PhD

Publish date: January 1, 2011

In the 1980s, the musical group Talking Heads sang, "You may ask yourself, How did I get here?"—an appropriate question as we begin our 80th year.<...

Article

Why is fixing the plumbing so difficult?

Author:: Brian F. Mandell, MD, PhD

Publish date: December 1, 2010

For carotid stenosis, a catheter-based procedure would seem safer than endarterectomy, but reality is not always so simple.

Article

Managing gout: How is it different in patients with chronic kidney disease?

Author:: Brian F. Mandell, MD, PhD

Publish date: December 1, 2010

The goals are the same, but the choice and dosage of drugs may need to be modified.

Article

Preventing clots: Don’t let the complex overshadow the simple

Author:: Brian F. Mandell, MD, PhD

Publish date: November 1, 2010

Although we often approach anticoagulation therapy with a confidence born of familiarity, it is not for the faint of heart.

Article

Finding the right target for treating Alzheimer disease

Author:: Brian F. Mandell, MD, PhD

Publish date: October 1, 2010

It is not always easy to pick a therapeutic target. Sometimes, potential targets are actually embers of the pathologic process rather than flames d...

Article

Exchanging the skin bleb for the test tube

Author:: Brian F. Mandell, MD, PhD

Publish date: September 1, 2010

New blood tests are a positive step towards accurate recognition and treatment of patients with latent tuberculosis.

Article

HIV: Just another chronic disease

Author:: Brian F. Mandell, MD, PhD

Publish date: August 1, 2010

Did we ever expect a time when HIV would be viewed as a chronic disease, with patients warranting screening for coronary artery disease in order to...

Article

Escaping the heat in the EMR pool

Author:: Brian F. Mandell, MD, PhD

Publish date: July 1, 2010

The electronic medical record (EMR) is a tool, and it performs at the skill level of the person using it.

Article

Preventing and treating acute gout attacks across the clinical spectrum: A roundtable discussion

Author:: Brian F. Mandell, MD, PhD

Publish date: June 1, 2010

Article

LVH and hypertension: Is treating the pressure not enough?

Author:: Brian F. Mandell, MD, PhD

Publish date: June 1, 2010

I am not sure the weight of current evidence supports routinely screening hypertensive patients for left ventricular hypertrophy using echocardiogr...

Article

The complexities of vitamin D

Author:: Brian F. Mandell, MD, PhD

Publish date: May 1, 2010

Patients with conditions as diverse as systemic lupus erythematosus and congestive heart failure seem to fare worse if they have lower vitamin D le...