Brian F. Mandell, MD, PhD

Article

Surprises and reaffirmations in 2008 clinical trials

Author:: Brian F. Mandell, MD, PhD

Publish date: January 1, 2009

Clinical trials in 2008 showed us that too much glucose is bad, but trying too hard to lower it may be worse. Low-density lipoprotein cholesterol p...

Article

Influenza: It’s right to bare arms

Author:: Brian F. Mandell, MD, PhD

Publish date: December 1, 2008

As busy as we are, it is worth spending extra time to aggressively promote immunization to our patients, our staff, and ourselves.

Article

The hospital guy redux

Author:: Brian F. Mandell, MD, PhD

Publish date: November 1, 2008

In the September issue of the Journal, Dr. Thomas Lansdale discussed the pressures that are eroding physician-patient relationships and th...

Article

When a quick sound bite won’t do

Author:: Brian F. Mandell, MD, PhD

Publish date: October 1, 2008

In the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, why did more patients die if they got intensive therapy than if they got s...

Article

And then there were none? An internist’s reflections

Author:: Brian F. Mandell, MD, PhD

Publish date: September 1, 2008

In this issue, Dr. Thomas Lansdale eloquently expresses a common theme: medicine just isn't that much fun anymore. We'd like to hear some solutions...

Article

Upgrades to our CME test and to www.ccjm.org

Author:: Brian F. Mandell, MD, PhD

Publish date: August 1, 2008

We recently upgraded our web-based manuscript tracking system, and we are continuing to expand and improve our educational offerings to our readers...

Article

Despite its treatability, gout remains a problem

Author:: Brian F. Mandell, MD, PhD

Publish date: July 1, 2008

Article

Clinical manifestations of hyperuricemia and gout

Author:: Brian F. Mandell, MD, PhD

Publish date: July 1, 2008

Article

A drug, a concept, and a clinical trial on trial

Author:: Brian F. Mandell, MD, PhD

Publish date: July 1, 2008

The ENHANCE trial, evaluating the addition of a second hypocholesterolemic drug (ezetimibe) to a statin using two surrogate end points in a relativ...

Article

Meta-analyses, metaphysics, and reality

Author:: Brian F. Mandell, MD, PhD

Publish date: June 1, 2008

Be very careful about directly translating conclusions from meta-analyses into clinical practice.

Article

‘Blood will have blood’

Author:: Brian F. Mandell, MD, PhD

Publish date: May 1, 2008

Why should more patients die when hemoglobin levels are normalized with erythropoiesis-stimulating agents? It could be another case of "messing wit...

Article

A new series, an old concept, continued value

Author:: Brian F. Mandell, MD, PhD

Publish date: April 1, 2008

This month we introduce a new series, The Physical Examination, kicked off by a paper on evaluating pleural effusions.

Article

A report from the department of staph affairs

Author:: Brian F. Mandell, MD, PhD

Publish date: March 1, 2008

The evolutionary pressure that we humans are putting on Staphylococcus aureus with our antibiotics is taking this bug to a whole new place...

Article

Surprisingly nonbenign imaging

Author:: Brian F. Mandell, MD, PhD

Publish date: February 1, 2008

Nephrogenic systemic fibrosis is making us revise our view that "MRI with contrast" is a benign test.

Article

A New Year's toast

Author:: Brian F. Mandell, MD, PhD

Publish date: January 1, 2008

With so many important clinical trials being published each year, it is easy to focus on the study methodology and conclusions, overlooking the yea...