The G.E interaction model appears to be consistent with the theory that expression of plasticity genes is modified by childhood experiences and environment, such as physical or sexual abuse. Some studies have found evidence of hypermethylation in BPD, which can exert epigenetic effects. Childhood abuse might, therefore, disrupt certain neuroplasticity genes, culminating in morphological, neurochemical, metabolic, and white-matter aberrations—leading to pathological behavioral patterns identified as BPD.
The neuropsychiatric basis of BPD must guide treatment There is no such thing as a purely psychological disorder: Invariably, it is an abnormality of brain circuits that disrupts normal development of emotions, thought, behavior, and social cognition. BPD is an exemplar of such neuropsychiatric illness, and treatment should support psychotherapeutic approaches to mend the mind at the same time it moves aggressively to repair the brain.