Does a second course of antenatal corticosteroids offer benefit in the setting of preterm PROM?
OBG Management. 2015 February;27(2):40-42
January 31, 2015|ObGyn
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No. Among 1,641 women in this secondary analysis of a prominent randomized controlled trial (RCT), there was no demonstrated benefit for a second course of antenatal corticosteroids (ACS) in the setting of preterm premature rupture of membranes (PROM). When a second course of corticosteroids was given, the rate of neonatal or maternal infection did not increase.
Gyamfi-Bannerman C, Son M. Preterm premature rupture of membranes and the rate of neonatal sepsis after two courses of antenatal corticosteroids. Obstet Gynecol. 2014;124(5):999–1003.
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