CHRONIC PELVIC PAIN
OBG Management. 2006 April;18(04):45-47
April 1, 2006|ObGyn
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ENDOMETRIOSIS Is surgery the best treatment?…Teenagers get endometriosis, too… Aromatase inhibitors
- Dose too low? Hefler and colleagues treated 10 patients with rectovaginal endometriosis, using a low dose (0.25 mg/day) of vaginal anastrozole, without much improvement in symptoms. They suggested that the dose may have been too low.
- Higher dose improved pain. Amsterdam and colleagues reported that pain improved in 15 of 18 patients who used anastrozole at a dosage of 1 mg/day by mouth. An oral contraceptive was given for hot flash control and prevention of bone mineral loss.
These results, along with other reports in the literature, are encouraging. It is now time for a controlled trial to investigate whether aromatase inhibitors are superior to placebo or other medical treatments for endometriosis.
The author has been a consultant for TAP Pharmaceuticals.
