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Tips for Tailoring Urinary Incontinence Therapy : Urinary incontinence affects women's 'confidence, sexuality, level of activity, and self-esteem.'


 

Urinary incontinence may rank as the most embarrassing condition a woman will face in her lifetime, but the good news is that 80%-90% of patients who seek treatment will experience symptom relief.

“That is what makes my job so great – the fact that I can bring back quality of life to these women,” said Dr. Cheryl Iglesia, who directs the Section of Female Pelvic Medicine and Reconstructive Surgery at Washington (D.C.) Hospital Center. “Urinary incontinence affects their confidence, sexuality, level of activity, and self-esteem.”

Treatments for stress, urge, and mixed urinary incontinence have expanded and advanced in recent years. Botox is the newest kid on the block, approved on Aug. 24 for the treatment of urinary incontinence in adults with neurologic conditions, including multiple sclerosis and spinal cord injury, that have an inadequate response to or are intolerant of anticholinergic medications.

“Like most of our therapies, Botox doesn't work for everyone but it can be very effective,” said Dr. Dee Ellen Fenner, professor of obstetrics and gynecology at the University of Michigan, Ann Arbor. “Overall, I think women tolerate it very well. It's done in the office with a cystoscope with injections into the bladder muscle.”

Before considering medical and surgical treatments for urinary incontinence, advise your patients to try conservative therapies first, such as limiting fluid intake (“let thirst be your guide”), cutting back on the intake of caffeine and other bladder irritants, and voiding on a schedule.

Strengthening the pelvic floor muscles with Kegel exercises also can be helpful. For a detailed description of Kegel exercises, visit www.voicesforpfd.org

Treatments for urinary incontinence differ depending on a woman's goals and her symptoms. For some women with stress incontinence, vaginal insertion of an incontinence dish pessary or an incontinence ring pessary will suffice. These devices act as a backstop to the urinary sphincter. “They're not as strong as surgery,” said Dr. Linda Brubaker, who directs the Division of Female Pelvic Medicine and Reconstructive Surgery at Loyola University Chicago, Maywood, Ill. “More people who have surgery will be satisfied and have better symptom control. But for a woman who doesn't want surgery or isn't ready for surgery who has symptoms only when she takes her Jazzercise class or goes for a run, a ring might work just fine.”

Dr. Fenner, who is also director of gynecology for the University of Michigan Health System, often recommends incontinence rings for mothers who experience urinary leakage after having a baby “because the tissues, muscles, and nerves in her pelvic region are healing for 9-12 months.” “Wearing that incontinence ring can be great.”

Other treatment options for stress incontinence include:

Urethral bulking agents. Food and Drug Administration-approved urethral bulking agents include collagen (Contigen), calcium hydroxylapatite (Coaptite), and carbon bead particles (Durasphere). These substances are injected along the urethra during an office procedure. “It doesn't take much anesthesia and patients can go home the same day,” said Dr. Iglesia. “Most people with a bulking agent will need a touch-up.”

Sling-type procedures. The mid-urethral mesh sling, most often made of polypropylene mesh, is the current standard. There are three different types: a retropubic sling that travels behind the pubic bone, forming a U shape; a transobturator sling, which exits through the groin crease near the thigh, forming more of an H shape; and newer mini slings, “which have no exit wounds at all; they're inserted into muscle via a single vaginal incision,” Dr. Iglesia said. Data on the retropubic sling surpassing 12 years “shows over 80% effectiveness in that patients are really satisfied – maybe not cured – but significantly improved with this procedure,” she said.

Mid-urethral slings for urinary incontinence “work very well but there are problems anytime you use an artificial material,” said Dr. Brubaker, who is also interim dean of medicine at Loyola University Chicago. “There are low but persistent rates of foreign body problems, but [these are] not much of an issue.”

Data on safety and effectiveness for retropubic and transobturator slings are robust but there is very limited data on long-term effectiveness of mini slings.

On July 13, the FDA issued a safety alert on serious complications associated with transvaginal placement of surgical mesh for pelvic organ prolapse. Prolapse mesh refers to much larger sheets of mesh compared with the straps of mesh used in slings. In a prepared statement, the American Urogynecologic Society pointed out that the conclusions and recommendations of the report “do not apply to the use of synthetic mesh for treatment of stress urinary incontinence … where the benefits of mesh are more clearly delineated and the risks are less.” The FDA Obstetrics and Gynecology Devices Panel of the Medical Devices Advisory Committee met on Sept. 8-9, and drew similar conclusions for slings.

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