Is Closed-Loop DBS Ready for Clinical Application?

Research indicates that the technique has advantages over conventional DBS and effectively treats Tourette syndrome and Parkinson’s disease.

Neurology Reviews. 2017 March;25(3):12

March 3, 2017|Neurology Reviews

—Erik Greb

Suggested Reading

Air EL, Ryapolova-Webb E, de Hemptinne C, et al. Acute effects of thalamic deep brain stimulation and thalamotomy on sensorimotor cortex local field potentials in essential tremor. Clin Neurophysiol. 2012;123(11):2232-2238.

de Hemptinne C, Swann NC, Ostrem JL, et al. Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson’s disease. Nat Neurosci. 2015;18(5): 779-786.

Miller KJ, Hermes D, Honey CJ, et al. Human motor cortical activity is selectively phase-entrained on underlying rhythms. PLoS Comput Biol. 2012;8(9):e1002655.

Okun MS, Foote KD, Wu SS, et al. A trial of scheduled deep brain stimulation for Tourette syndrome: moving away from continuous deep brain stimulation paradigms. JAMA Neurol. 2013;70(1):85-94.